Kazuaki Nakamura Selected Research

pyrimidin-2-one beta-ribofuranoside

1/2017	Zebularine upregulates expression of CYP genes through inhibition of DNMT1 and PKR in HepG2 cells.
1/2015	DNA methyltransferase inhibitor zebularine induces human cholangiocarcinoma cell death through alteration of DNA methylation status.
1/2013	DNA methyltransferase inhibitor zebularine inhibits human hepatic carcinoma cells proliferation and induces apoptosis.

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Kazuaki Nakamura Research Topics

Disease

4	Neuroblastoma 01/2011 - 07/2009
4	Leprosy (Hansen's Disease) 11/2010 - 12/2008
3	Insulin Resistance 02/2011 - 01/2009
2	Drug-Related Side Effects and Adverse Reactions 01/2017 - 01/2011
2	Hepatocellular Carcinoma (Hepatoma) 01/2015 - 01/2013
2	Glucose Intolerance 02/2011 - 06/2009
2	Hypoglycemia (Reactive Hypoglycemia) 02/2011 - 06/2009
2	Hyperglycemia 02/2011 - 06/2009
2	Ischemia 09/2007 - 01/2006
1	Hyperammonemia 10/2020
1	Wounds and Injuries (Trauma) 01/2020
1	Neoplasms (Cancer) 01/2015
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2015
1	Cholangiocarcinoma 01/2015
1	Biliary Atresia 09/2014
1	Protein Deficiency 06/2014
1	Ornithine Carbamoyltransferase Deficiency Disease 03/2014
1	Peripheral Nervous System Diseases (PNS Diseases) 10/2013
1	Carcinoma (Carcinomatosis) 01/2013
1	Retinal Degeneration 02/2011
1	Ectrodactyly 01/2011
1	Intellectual Disability (Idiocy) 01/2011
1	Microcephaly 01/2011
1	Microphthalmos 01/2011
1	Prognathism 01/2011
1	Mood Disorders (Mood Disorder) 12/2010
1	Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy) 11/2010
1	Type 2B Charcot-Marie-Tooth disease 11/2010
1	Communicable Diseases (Infectious Diseases) 08/2010
1	Body Remains 08/2010
1	Bipolar Disorder (Manic Depressive Psychosis) 11/2009
1	Infections 02/2009
1	Body Weight (Weight, Body) 12/2007
1	Low Tension Glaucoma 07/2007
1	Diabetic Retinopathy (Retinopathy, Diabetic) 12/2006
1	Epiretinal Membrane (Epiretinal Membranes) 12/2006
1	Pendred syndrome 02/2002

Drug/Important Bio-Agent (IBA)

4	Pharmaceutical PreparationsIBA 10/2020 - 11/2009
4	Proteins (Proteins, Gene)FDA Link 06/2014 - 12/2008
3	pyrimidin-2-one beta-ribofuranosideIBA 01/2017 - 01/2013
3	DNA (Deoxyribonucleic Acid)IBA 01/2015 - 08/2010
3	Vasopressins (Vasopressin)IBA 02/2011 - 01/2009
3	RNA (Ribonucleic Acid)IBA 11/2010 - 02/2009
2	A-Form DNA (A-DNA)IBA 01/2015 - 01/2013
2	MethyltransferasesIBA 01/2015 - 01/2013
2	Indicators and Reagents (Reagents)IBA 01/2015 - 02/2009
2	Glutamic Acid (Glutamate)FDA Link 02/2011 - 07/2007
2	Sorting NexinsIBA 01/2011 - 11/2009
2	p38 Mitogen-Activated Protein KinasesIBA 09/2007 - 01/2006
1	Oxytocin (Pitocin)FDA LinkGeneric 01/2020
1	ArsenicIBA 01/2015
1	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 09/2014
1	cytohesin-1IBA 10/2013
1	mono(2-methacryloyloxy)ethyl phthalate (MMEP)IBA 01/2011
1	EnzymesIBA 01/2011
1	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 12/2010
1	Monomeric GTP-Binding ProteinsIBA 11/2010
1	Valproic Acid (Depakote)FDA LinkGeneric 11/2010
1	Mutant Proteins (Protein, Mutant)IBA 11/2010
1	LithiumIBA 11/2009
1	4- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA 11/2009
1	cytohesin-2IBA 07/2009
1	Glucose (Dextrose)FDA LinkGeneric 06/2009
1	Vasopressin Receptors (Arginine Vasopressin Receptor)IBA 06/2009
1	Insulin (Novolin)FDA Link 06/2009
1	Therapeutic UsesIBA 02/2009
1	4,6- diphenyl- 3- (4- (pyrimidin- 2- yl)piperazin- 1- yl)pyridazineIBA 12/2007
1	geranylgeranylacetone (teprenone)IBA 09/2007
1	Retinaldehyde (Retinal)IBA 09/2007
1	Neuroprotective AgentsIBA 09/2007
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 12/2006
1	NF-kappa B (NF-kB)IBA 12/2006
1	IodidesIBA 02/2002

Therapy/Procedure

1	Drug Therapy (Chemotherapy) 01/2015
1	Transplantation 03/2014
1	Therapeutics 10/2013
1	Oral Administration 12/2007
1	Vitrectomy 12/2006